Ophthalmic Antibiotic (oxytetracycline hydrochloride) Antibiotic with Polymyxin B Sulfate
Active Ingredient(s): TERRAMYCIN Ophthalmic Ointment with polymyxin B sulfate is a suspension of oxytetracycline hydrochloride and polymyxin B sulfate in a special petrolatum base. Each gram of ointment contains oxytetracycline HCl equivalent to 5 mg of oxytetracycline and 10,000 units of polymyxin B as the sulfate.
Indications: TERRAMYCIN Ophthalmic Ointment with polymyxin B sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline- and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.
Pharmacology: TERRAMYCIN (oxytetracycline HCl) is an antibiotic, bright yellow in color, possessing potent antimicrobial activity. It is one of the most versatile of the broad-spectrum antibiotics, and is effective in the treatment of infections due to gram-positive and gram-negative bacteria, both aerobic and anaerobic, spirochetes, rickettsiae, and certain of the larger viruses. Polymyxin B sulfate is one of a group of related antibiotics derived from Bacillus polymyxa. The polymyxins are rapidly bactericidal, this action being exclusively against gram-negative bacteria. The broad-spectrum effectiveness of TERRAMYCIN against both gram-positive and gram-negative organisms is enhanced by the particular effectiveness of polymyxin B against infections associated with gram-negative organisms, especially those due to Pseudomonas aeruginosa, where polymyxin B is the antibiotic of choice. In addition, there is evidence to indicate that polymyxin B sulfate possesses some antifungal activity. The combined antibacterial effect of TERRAMYCIN plus polymyxin is at least additive and, in many instances, an actual synergistic action is obtained.
Dosage and Administration: TERRAMYCIN Ophthalmic Ointment with polymyxin B sulfate should be administered topically to the eye 2-4 times daily. Presentation: Available in 1/8 oz. tubes.