What are Glucosamine and Chondroitin? Glucosamine and chondroitin are normal substances found in the bodies of living animals. They are at their highest concentration in cartilage. Unfortunately, through degradation during digestion and processing, almost all of the glucosamine in an animal's diet is unavailable for use. The body, therefore, synthesizes most of its own glucosamine through a biochemical reaction utilizing glucose.

In normal healthy animals the body is able to synthesize enough glucosamine to keep the existing cartilage healthy. When the animal ages or there is damage to joint cartilage it cannot produce enough to keep up with the body's needs. This is where a supplemental form of glucosamine is needed.

The way that glucosamine works is a very complicated process. In a nutshell, cartilage consists of several different cells one type of which are chondrocytes. Chondrocytes are responsible for synthesizing new cartilage. Through normal wear, cartilage is constantly being broken down and replaced. When a dog has hip dysplasia or ages, the chondrocytes don't have the building blocks available to build enough new cartilage to keep up with the breakdown of the old cartilage. Glucosamine provides the building blocks to synthesize new cartilage. Glucosamine is the building block necessary for the production of the substances called glycosaminoglycans. The glycosaminoglycans are combined with hyaluronic acid to make proteoglycans. The proteoglycans and collagen are the main structures of cartilage.

Chondroitin is also one of the products necessary for the synthesis of glycosaminoglycans. But it probably plays a more important role by combating and neutralizing destructive enzymes in the joint. There is always a low level of destructive enzymes found in the joint, but when injury or abnormal wear occurs, the destructive enzymes and agents increase accelerating cartilage destruction. When chondroitin is added to the diet it helps to reduce the level of these destructive enzymes.

Ingredients: Microcrystalline Cellulose, Dextrose, Xanthan Gum, Vegetable Oil, Artificial Roast Beef Flavor, Salt, Natural and Artificial Cheese Flavor, Dried Brewers Yeast, Natural Garlic flavor.

Each Chewable Tablet contains: Glucosamine 500 mg. - Chondroitin 400 mg. - Vitamin C 33 mg. - Manganese 5 mg.

Double Strength Chewables: For dogs. Suggested daily use: Dogs under 10 lbs: 1/2 chewable tablet; 10-24 lbs: 1 chewable tablet; 25-49 lbs: 2 chewable tablets; 50-100 lbs: 3 chewable tablets (2 in the a.m. and 1 in the p.m.); over 100 lbs: 2 chewable tablets twice daily.

After first 6-week period: Dogs 25-49 lbs can have total daily dosage lowered in increments of a 1/2 capsule daily per month until maintenance level is reached. Dogs over 49 lbs can have their total daily dosage lowered in increments of 1 capsule daily per month until maintenance level is reached.